Jan Lammerding Selected Research

Emery-Dreifuss Muscular Dystrophy (Scapuloperoneal Muscular Dystrophy)

1/2020	Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells.
5/2013	Lamin A/C and emerin regulate MKL1-SRF activity by modulating actin dynamics.
9/2011	Biophysical assays to probe the mechanical properties of the interphase cell nucleus: substrate strain application and microneedle manipulation.
1/2009	Mechanical properties of interphase nuclei probed by cellular strain application.
7/2007	Cell nuclei spin in the absence of lamin b1.
9/2006	Lamins A and C but not lamin B1 regulate nuclear mechanics.
8/2005	Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells.
1/2005	The nuclear membrane and mechanotransduction: impaired nuclear mechanics and mechanotransduction in lamin A/C deficient cells.
2/2004	Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction.

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Jan Lammerding Research Topics

Disease

18	Neoplasms (Cancer) 01/2022 - 01/2009
11	Muscular Dystrophies (Muscular Dystrophy) 01/2020 - 07/2007
10	Rupture 03/2022 - 04/2016
10	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 11/2019 - 02/2004
9	Emery-Dreifuss Muscular Dystrophy (Scapuloperoneal Muscular Dystrophy) 01/2020 - 02/2004
8	Laminopathies 01/2020 - 02/2004
8	Neoplasm Metastasis (Metastasis) 01/2018 - 01/2009
8	Progeria (Hutchinson Gilford Syndrome) 05/2013 - 02/2004
3	Breast Neoplasms (Breast Cancer) 12/2019 - 06/2017
3	Cardiomyopathies (Cardiomyopathy) 12/2011 - 01/2009
2	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 05/2013 - 09/2011
2	Blister (Bulla) 07/2010 - 09/2006
2	Heart Failure 04/2009 - 12/2002
1	Ataxia Telangiectasia (Louis Bar Syndrome) 01/2022
1	Pancreatitis 01/2022
1	Inflammation (Inflammations) 01/2022
1	Noninfiltrating Intraductal Carcinoma (DCIS) 12/2019
1	Fibrosarcoma 01/2019
1	Glioblastoma (Glioblastoma Multiforme) 01/2019
1	Carcinogenesis 01/2019
1	Chromosomal Instability (Chromosome Stability) 01/2018
1	Bites and Stings (Sting) 01/2018
1	Genomic Instability 11/2016
1	Circulating Neoplastic Cells 12/2015
1	Necrosis 12/2015
1	Premature Aging 12/2013
1	Muscular Diseases (Myopathy) 06/2013
1	Pelger-Huet Anomaly 03/2013
1	Aneuploidy (Aneuploid) 03/2011
1	Hypertrophy 07/2009
1	Desmin-Related Myofibrillar Myopathy 04/2009
1	Muscle Weakness 03/2006

Drug/Important Bio-Agent (IBA)

18	Proteins (Proteins, Gene)FDA Link 01/2020 - 08/2005
17	LaminsIBA 01/2020 - 09/2006
16	Lamin Type A (Lamin A)IBA 01/2022 - 02/2004
3	ChromatinIBA 01/2019 - 03/2011
2	emerinIBA 05/2013 - 08/2005
2	prelamin AIBA 07/2010 - 03/2006
2	lamin CIBA 07/2010 - 03/2006
1	polyacrylamideIBA 03/2022
1	Chemokine ReceptorsIBA 01/2022
1	Phosphotransferases (Kinase)IBA 01/2022
1	CytokinesIBA 01/2022
1	Pharmaceutical PreparationsIBA 01/2022
1	HydrogelsIBA 12/2021
1	Durapatite (Hydroxylapatite)IBA 12/2019
1	Polyglactin 910IBA 12/2019
1	MineralsIBA 12/2019
1	Interleukin-8 (Interleukin 8)IBA 12/2019
1	Biomarkers (Surrogate Marker)IBA 11/2019
1	Myosins (Myosin)IBA 01/2019
1	theasinensin AIBA 01/2019
1	Lamin Type B (Lamin B)IBA 01/2019
1	Indicators and Reagents (Reagents)IBA 01/2019
1	Protein Isoforms (Isoforms)IBA 01/2019
1	Nonmuscle Myosin Type IIAIBA 01/2019
1	Myosin Type IIIBA 01/2019
1	DNA (Deoxyribonucleic Acid)IBA 01/2018
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2018
1	Biological ProductsIBA 01/2018
1	InterferonsIBA 01/2018
1	IntegrinsIBA 06/2017
1	PaxillinIBA 06/2017
1	src-Family KinasesIBA 06/2017
1	Endosomal Sorting Complexes Required for TransportIBA 01/2017
1	ATPases Associated with Diverse Cellular ActivitiesIBA 01/2017
1	PlasticsIBA 10/2016
1	Lamin B ReceptorIBA 03/2013
1	p21(ras) farnesyl-protein transferase (protein farnesyltransferase)IBA 03/2011
1	alpha-Crystallins (alpha-Crystallin)IBA 07/2009
1	DesminIBA 04/2009
1	Crystallins (Crystallin)IBA 04/2009
1	Farnesyltranstransferase (Farnesyltransferase)IBA 06/2008
1	Cytoskeletal ProteinsIBA 07/2007
1	EnzymesIBA 03/2006
1	Matrix Metalloproteinases (MMPs)IBA 12/2002

Therapy/Procedure

4	Therapeutics 01/2019 - 12/2002
2	Traction 03/2022 - 06/2017
1	Drug Therapy (Chemotherapy) 01/2018
1	Lab-On-A-Chip Devices 01/2018